How Low Cholesterol Is Good for Anti-viral Immunity
نویسنده
چکیده
York et al. identify a role for decreased cholesterol biosynthesis in virally infected cells as a critical event in the induction of the anti-viral response. The mechanism involves enhanced signaling by STING in the ER membrane in response to the second messenger cGAMP, promoting increased transcription of type I interferons. The authors suggest that a "lipid code" is being sensed by STING to allow it to signal.
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عنوان ژورنال:
- Cell
دوره 163 شماره
صفحات -
تاریخ انتشار 2015